Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.
JT Huang, RJ Schneider - Proceedings of the National …, 1990 - National Acad Sciences
Adenovirus infection results in the suppression of cellular protein synthesis, but the
mechanism has not been established. In this report we demonstrate that the shut-off of
cellular protein synthesis by adenovirus is prevented in cells by treatment with the drug 2-
aminopurine. Treatment with 2-aminopurine is shown to prevent suppression of cellular
translation without disrupting the normal viral block in the transport of cellular mRNAs from
the nucleus to the cytoplasm. We show that viral suppression of cellular protein synthesis …
mechanism has not been established. In this report we demonstrate that the shut-off of
cellular protein synthesis by adenovirus is prevented in cells by treatment with the drug 2-
aminopurine. Treatment with 2-aminopurine is shown to prevent suppression of cellular
translation without disrupting the normal viral block in the transport of cellular mRNAs from
the nucleus to the cytoplasm. We show that viral suppression of cellular protein synthesis …
